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KMID : 0882420140870030323
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Korean Journal of Medicine
2014 Volume.87 No. 3 p.323 ~ p.327
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A Case of Hyponatraemic Seizure Following Terlipressin Therapy fora Variceal Hemorrhage in a Patient with Liver Cirrhosis
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Kim Jin-Hee
Kim Ja-Kyung
Mun So-Yeong
Choi Chung-Jo
Park Han-Min
Jeong Yong-Seol
Kang Jun-Goo
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Abstract
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Terlipressin has splanchnic vasoconstrictive effects, and is generally used for the management of gastroesophageal variceal bleeding secondary to liver cirrhosis. Terlipressin is a synthetic arginine vasopressin (AVP) analog containing a nonapeptide sequence. Terlipressin has increased selectivity for the V1 receptor, compared with AVP; hence, it is considered to be a safe vasoconstrictor. However, side effects such as hyponatremia and seizure, although very rare, have been reported. Hyponatremia related to terlipressin may be caused by the syndrome of inappropriate antidiuresis (SIAD), which is a disorder of sodium and water balance characterized by hypotonic hyponatremia without elevation of the antidiuretic hormone level. Here, we report a case of hyponatremic seizure induced by an infusion of terlipressin in a 52-year-old female who had isolated gastric variceal bleeding secondary to alcoholic liver cirrhosis.
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KEYWORD
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Terlipressin, Hyponatremia, Seizure
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